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Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents |
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| Authors: | Burchak Olga N Pihive Emmanuelle Le Maigre Laure Guinchard Xavier Bouhours Pascale Jolivalt Claude Schneider Dominique Maurin Max Giglione Carmela Meinnel Thierry Paris Jean-Marc Denis Jean-Noël |
| Institution: | Département de Chimie Moléculaire, UMR, CNRS, Université Joseph Fourier, Grenoble, France. olga.burchak@ujf-grenoble.fr |
| Abstract: | A collection of 3-substituted indole derivatives was prepared using nucleophilic addition of indoles to nitrones. The compounds were then tested for their antibacterial activity against almost thirty bacterial strains representative of common human pathogens. Two types of indolic molecules inhibit the growth of Staphylococcus aureus, including MRSA and VISA strains, with MIC values ranging from 8 to 16 mg/L. |
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