Regional localization by in situ hybridization of a human chromosome 9 marker tightly linked to the Friedreich's ataxia locus |
| |
| Authors: | Elena Raimondi Antonella Antonelli Albert J Driesel Massimo Pandolfo |
| |
| Institution: | (1) Dipartimento di Genetica e Microbiologia,  A.Buzzati Traverso dell'Universitá di Pavia, Via S. Epifanio, 16, I-27100 Pavia, Italy;(2) Divisione di Biochimica e Genetica del Sistema Nervoso, Istituto Neurologico, C. Besta, Via Celoria, 11, I-20133 Milano, Italy;(3) Dechema-Institut, Theodor-Heuss-Allee 25, D-6000 Frankfurt, Federal Republic of Germany |
| |
| Abstract: | Summary In order to determine the regional localization of the Friedreich's ataxia (FA) gene on chromosome 9, the DNA probe DR47 (D9S5), which detects a restriction fragment length polymorphism (RFLP) in tight linkage with the disease, was hybridized in situ to metaphase chromosomes. Our results enable the D9S5 locus to be assigned to the 9q12–q13 region, thus indicating that this is also the localization of the FA gene. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
