Mapping of the bcl-2 oncogene on mouse chromosome 1 |
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| Authors: | B A Mock D Givol L A D'Hoostelaere K Huppi M F Seldin N Gurfinkel T Unger M Potter J F Mushinski |
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| Institution: | Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892. |
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| Abstract: | Two bcl-2 alleles have been identified in inbred strains of mice by restriction fragment length polymorphism (RFLP). Analysis of a bcl-2 RFLP in a series of bilineal congenic strains (C.D2), developed as a tool for chromosomal mapping studies, revealed linkage of bcl-2 to the Idh-1/Pep-3 region of murine chromosome 1. The co-segregation of bcl-2 alleles with allelic forms of two other chromosome 1 loci, Ren-1,2 and Spna-1, in a set of back-cross progeny, positions bcl-2 7.8 cM centromeric from Ren-1,2. |
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