Evaluation of chromosomal aberrations in bone marrow of 1C3F1 mice |
| |
Authors: | I D Adler I Ingwersen |
| |
Institution: | GSF-Institut für S?ugetiergenetik, Neuherberg, F.R.G. |
| |
Abstract: | The chemical caprolactam (CAP) was tested for induction of chromosomal aberrations in bone marrow of male and female 1C3F1 mice at a single dose of 1000 mg/kg by oral intubation of an aqueous solution at a volume of 0.1 ml/10 g of body weight. Bone marrow was sampled from groups of 10 animals 24, 30 and 48 h after treatment. CAP did not produce chromosomal aberrations under the present experimental conditions. At the same time, benzoa]pyrene, used as a positive control, significantly increased the aberration rates at a dose of 63 mg/kg. |
| |
Keywords: | |
|
|