Effects of Acute Clomipramine Administration on Syrian Hamster Circadian Rhythms

Drugs linked to the serotonergic system, like antidepressants, are able to modify the circadian system. The present experiments were designed to test whether clomipramine, a 5-HT reuptake inhibitor, was able to modify: a) the phase of free running activity rhythms; b) the light-induced phase shifts in Syrian hamsters. Clomipramine had a phase-dependent effect on the free running activity rhythm, with phase advances at CT 0-8 being significantly higher than at CT 8-16. Pretreatment with clomipramine inhibited phase advances in response to light pulses when applied at CT 19 while delays remained unaffected. The results suggest that acute clomipramine treatment can affect the expression of the circadian rhythmicity in Syrian hamsters.