Construction of the simplest model to explain complex receptor activation kinetics |
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Authors: | Bywater R P Sørensen A Røgen P Hjorth P G |
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Institution: | Biostructure Department, Novo Nordisk A/S, Novo Nordisk Park, DK-2760, M?l?v, Denmark. |
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Abstract: | We study the mathematical solutions to the kinetic equations arising from various simple ligand-receptor corrected] models. Focusing on the prediction of the various models for the activity vs. concentration curve, we find that solutions to the kinetic equations arising from the so-called dimer model exhibit features observed in some experiments, most noticeably a distinct maximum in the activity curve. |
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