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Construction of the simplest model to explain complex receptor activation kinetics
Authors:Bywater R P  Sørensen A  Røgen P  Hjorth P G
Institution:Biostructure Department, Novo Nordisk A/S, Novo Nordisk Park, DK-2760, M?l?v, Denmark.
Abstract:We study the mathematical solutions to the kinetic equations arising from various simple ligand-receptor corrected] models. Focusing on the prediction of the various models for the activity vs. concentration curve, we find that solutions to the kinetic equations arising from the so-called dimer model exhibit features observed in some experiments, most noticeably a distinct maximum in the activity curve.
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