| 间歇性低压低氧通过促进细胞凋亡抗大鼠胶原诱导性关节炎 |
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| 作者姓名： | Shi M Cui F Liu AJ Li J Ma HJ Cheng M Yang J Zhang Y |
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| 作者单位： | 河北医科大学生理学教研室;河北医科大学第二医院检验科;河北医科大学第二医院免疫风湿科; |
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| 基金项目： | supported by the National Basic Research Development Program of China(No.2006CB504100); the National Natural Science Foundation of China(No.30393130,30572086 and 31071002); the Special Foundation for the Doctoral Point in High Educational Institute of China(No.20060089009); the Medical Science Research Foundation of Health Bureau of Hebei Province,China(No.05084,20100071); the Guidance Project of Science and Technology Bureau,Hebei Province,China(No.07276172,11276103D-56) |
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| 摘 要： | 本文旨在研究慢性间歇性低压低氧(chronic intermittent hypobaric hypoxia,CIHH)对大鼠胶原诱导性关节炎(collagen-induced arthritis,CIA)影响.雄性成年Sprague-Dawley大鼠50只,随机分为5组:CIHH预处理组(Pre-T)、预处理对照组(...
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| 关 键 词： | 胶原诱导性关节炎 慢性间歇性低压低氧 细胞凋亡 T淋巴细胞 大鼠 |
Protection of chronic intermittent hypobaric hypoxia against collagen-induced arthritis in rat through increasing apoptosis |
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| Shi M,Cui F,Liu AJ,Li J,Ma HJ,Cheng M,Yang J,Zhang Y.Protection of chronic intermittent hypobaric hypoxia against collagen-induced arthritis in rat through increasing apoptosis[J].Acta Physiologica Sinica,2011,63(2):115-123. |
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| Authors: | Shi Min Cui Fang Liu Ai-Jing Li Jiao Ma Hui-Juan Cheng Ming Yang Jing Zhang Yi |
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| Institution: | SHI Min1,2,CUI Fang1,LIU Ai-Jing3,LI Jiao2,MA Hui-Juan1,CHENG Ming1,YANG Jing1,ZHANG Yi1,1Department of Physiology,Hebei Medical University,2Department of Clinical Laboratory,Second Hospital,3Department of Immune and Rheumatism,Shijiazhuang 050017,China |
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| Abstract: | The aim of present study was to investigate the effect of chronic intermittent hypobaric hypoxia(CIHH) on collagen-induced arthritis(CIA) in rat.Fifty male adult Sprague-Dawley rats were randomly divided into 5 groups:CIHH pre-treatment group(Pre-T),pre-control group(Pre-C),CIHH post-treatment group(Post-T),post-control group(Post-C) and blank control group(Con).The rats in Pre-T and Post-T groups were exposed to 28 d of hypobaric hypoxia(simulated 3 000 m altitude,5 h per day,pO2=108.8 mmHg,14% O2) in a hy... |
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| Keywords: | collagen-induced arthritis chronic intermittent hypobaric hypoxia cell apoptosis T lymphocytes rat |
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