| 大鼠坐骨神经挤压损伤导致脊髓单突触反射回返性抑制的长时程减弱 |
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| 作者姓名： | Shu L Dong YR Yan WH Zhai Y Wang Y Li W |
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| 作者单位： | 上海交通大学医学院附属第九人民医院;复旦大学脑科学研究院医学神经生物学国家重点实验室; |
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| 摘 要： | 坐骨神经损伤是临床常见的周围神经疾病。神经损伤后再生肌肉和运动神经元会出现各种功能障碍,虽然其中一部分因素已被阐明,但多局限于受损神经局部,而对于再生后脊髓运动神经元的回返性抑制(recurrent inhibition,RI)通路的功能变化却很少被报道。本文研究大鼠短暂坐骨神经损伤后,恢复神经再支配(reinnervation)情况下,脊髓RI通路的功能变化。在正常或坐骨神经挤压(crush)受损后的成年大鼠上,通过刺激离断的脊髓背根(L5),在外侧腓肠肌-比目鱼肌(lateral gas-trocnemius-soleus,LG-S)神经或内侧腓肠肌(medial gastrocnemius,MG)神经记录单突触反射(monosynaptic reflex,MSR),并同时在另一神经给予条件性刺激,以检测LG-S和MG运动神经元间RI的变化。结果显示:(1)脊髓运动神经元的RI在坐骨神经挤压受损后即基本丢失(<5周),至损伤6周后部分恢复至正常的50%,并至少维持至损伤14周后;(2)一侧的坐骨神经损伤对对侧的RI没有影响;(3)外周神经损伤后,免疫组织化学方法显示脊髓运动神经元数目本身并不发生减少。以上...
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| 关 键 词： | 坐骨神经 神经挤压 脊髓 回返性抑制 |
Long term depression of the recurrent inhibition of monosynaptic spinal reflexes after sciatic nerve crush in adult rats |
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| Shu L,Dong YR,Yan WH,Zhai Y,Wang Y,Li W.Long term depression of the recurrent inhibition of monosynaptic spinal reflexes after sciatic nerve crush in adult rats[J].Acta Physiologica Sinica,2011,63(4):291-299. |
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| Authors: | Shu Liang Dong You-Rong Yan Wei-Hong Zhai Yu Wang Yun Li Wei |
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| Institution: | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China. |
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| Abstract: | Sciatic nerve injury is a common disease of peripheral nerve in clinic. After nerve injury, there are many dysfunctions in motoneurons and muscles following regeneration. Previous studies mostly investigated the aspects related to the injured nerve, and the effect on the recurrent inhibition (RI) pathway of spine following regeneration was not fully understood. Following reinnervation after temporary sciatic nerve crush, the functional alteration of RI was studied. In adult rats, RI between lateral gastrocn... |
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| Keywords: | sciatic nerve nerve crush spine recurrent inhibition |
| 本文献已被 CNKI PubMed 等数据库收录！ |
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