| 热性癫痫发作大鼠海马齿状回外侧支的可塑性和再可塑性 |
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| 作者姓名： | Zhang L Luo XP |
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| 作者单位： | 华中科技大学同济医学院附属同济医院儿科; |
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| 基金项目： | supported by the National Natural Science Foundation of China(No.30872796) |
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| 摘 要： | 热性癫痫发作是儿童常见病,能损害认知功能,而突触可塑性和再可塑性(metaplasticity)是维系大脑认知功能的重要神经基础.本文通过脑片灌流和细胞外场电位记录术研究了热性癫痫发作大鼠海马齿状回外侧支的突触可塑性和再可塑性.制作对照组和热性癫痫发作组大鼠的脑切片后,记录电极置于齿状回外侧支的外分子层获取兴奋性突触后...
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| 关 键 词： | 热性癫痫发作 海马 突触可塑性 预先刺激 |
Plasticity and metaplasticity of lateral perforant path in hippocampal dentate gyrus in a rat model of febrile seizure |
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| Zhang L,Luo XP.Plasticity and metaplasticity of lateral perforant path in hippocampal dentate gyrus in a rat model of febrile seizure[J].Acta Physiologica Sinica,2011,63(2):124-130. |
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| Authors: | Zhang Lian Luo Xiao-Ping |
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| Institution: | ZHANG Lian,LUO Xiao-Ping Department of Pediatrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China |
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| Abstract: | Febrile seizure(FS) is common in childhood and can impair cognitive function.The potential to exhibit plasticity at many synapses appears to be modulated by prior synaptic activity.This intriguing higher-order form of plasticity has been termed metaplasticity.Plasticity and metaplasticity have been considered to be one of the most important neurological fundaments of learning and memory.In the present study,field potential recording was carried out to detect the effects of FS on plasticity and metaplasticit... |
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| Keywords: | febrile seizure hippocampus synaptic plasticity priming stimulation |
| 本文献已被 CNKI PubMed 等数据库收录！ |
