| 早期干预ERK在脊髓的激活可阻断外周神经损伤引起的神经病理性疼痛的发生 |
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| 作者姓名： | Han M Huang RY Du YM Zhao ZQ Zhang YQ |
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| 作者单位： | 复旦大学神经生物学研究所脑科学研究院医学神经生物学国家重点实验室;复旦大学生命科学学院; |
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| 基金项目： | supported by the National Natural Science Foundation of China(No.30870835,30821002,30900444 and 31070973); National Basic Research Development Program of China(No.2007CB512303 and 2007CB512502) |
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| 摘 要： | 本文采用大鼠坐骨神经慢性压迫损伤引起的神经病理痛模型,研究脊髓背角细胞外信号调节激酶(extracellular signal-regulatedkinase,ERK)在外周神经损伤引起的神经病理疼痛发生中的作用.结果显示,单侧坐骨神经压迫性损伤后1天,大鼠损伤侧脊髓背角ERK的磷酸化(激活)水平显著上调,其下游转录因...
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| 关 键 词： | 触诱发痛 痛觉过敏 ERK-CREB信号通路 早期干预 脊髓 大鼠 |
Early intervention of ERK activation in the spinal cord can block initiation of peripheral nerve injury-induced neuropathic pain in rats |
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| Han M,Huang RY,Du YM,Zhao ZQ,Zhang YQ.Early intervention of ERK activation in the spinal cord can block initiation of peripheral nerve injury-induced neuropathic pain in rats[J].Acta Physiologica Sinica,2011,63(2):106-114. |
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| Authors: | Han Mei Huang Ru-Yi Du Yi-Min Zhao Zhi-Qi Zhang Yu-Qiu |
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| Institution: | HAN Mei1,HUANG Ru-Yi2,DU Yi-Min2,ZHAO Zhi-Qi1,ZHANG Yu-Qiu1,1Institute of Neurobiology,Institute of Brain Science and State Key Laboratory of Medical Neurobiology,Shanghai Medical College,Fudan University,Shanghai 200032,China,2Department of Life Science,Shanghai 200433 |
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| Abstract: | The present study is to investigate whether the extracellular signal-regulated kinase(ERK) and cAMP response element binding protein(CREB) signaling pathway contributes to the initiation of chronic constriction injury(CCI)-induced neuropathic pain in rats.Mechanical allodynia was assessed by measuring the hindpaw withdrawal threshold in response to a calibrated series of von Frey hairs.Thermal hyperalgesia was assessed by measuring the latency of paw withdrawal in response to a radiant heat source.The expre... |
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| Keywords: | allodynia hyperalgesia ERK-CREB signaling pathway early intervention spinal cord rats |
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