| 一氧化氮对失血性休克大鼠离体淋巴管收缩性双相变化的调节作用 |
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| 引用本文： | Qin LP,Niu CY,Zhao ZG,Zhang J,Zhang YP. 一氧化氮对失血性休克大鼠离体淋巴管收缩性双相变化的调节作用[J]. 生理学报, 2011, 63(4): 367-376 |
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| 作者姓名： | Qin LP Niu CY Zhao ZG Zhang J Zhang YP |
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| 作者单位： | 河北北方学院微循环研究所基础医学院病理生理教研室; |
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| 基金项目： | supported by the National Natural Science Foundation of China(No.30770845); the Natural Science Foundation of Hebei Province,China(No.C2008000503); the Scientific Research Key Project of Department of Education in Hebei Province,China(No.ZH2007101) |
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| 摘 要： | 本文旨在离体观察失血性休克后不同时间淋巴管的收缩性变化及一氧化氮(nitric oxide,NO)的作用。分离失血性休克进程中不同时间点(0,0.5,1,2,3h)的大鼠胸导管条,采用微血管压力-直径测定技术,离体观察淋巴管在不同跨壁压(1,3,5,7,9cmH2O)下的收缩频率(contraction frequency,CF)、收缩末期口径(end diastolic diameter,EDD)、舒张末期口径(end systolicdiameter,ESD)、被动管径(passive diameter,PD)的变化,计算淋巴管的收缩幅度(contraction amplitude,CA)、紧张性指数(tonicindex,TI)和泵流分数(fractional pump flow,FPF)。结果显示,在多个跨壁压下,休克0h、休克0.5h淋巴管的CF、TI、FPF显著高于对照组,随着休克的发展,休克2h和休克3h淋巴管在多个跨壁压下的CF、TI、FPF显著低于对照组。用NO相关的工具药单独或联合孵育休克0.5h和休克2h的淋巴管,然后在3cmH2O跨壁压条件下测定淋巴管的收缩性。NO供体L-Arg使休克...
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| 关 键 词： | 休克 失血性 淋巴管 收缩性 一氧化氮 |
Nitric oxide modulates biphasic changes of isolated lymphatic contraction in hemorrhagic shock rats |
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| Qin Li-Peng,Niu Chun-Yu,Zhao Zi-Gang,Zhang Jing,Zhang Yu-Ping. Nitric oxide modulates biphasic changes of isolated lymphatic contraction in hemorrhagic shock rats[J]. Acta Physiologica Sinica, 2011, 63(4): 367-376 |
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| Authors: | Qin Li-Peng Niu Chun-Yu Zhao Zi-Gang Zhang Jing Zhang Yu-Ping |
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| Affiliation: | QIN Li-Peng,NIU Chun-Yu *,ZHAO Zi-Gang,ZHANG Jing,ZHANG Yu-Ping Institute of Microcirculation,Department of Pathophysiology of Basic Medical College,Hebei North University,Zhangjiakou 075000,China |
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| Abstract: | The aim of the present study was to investigate the changes of lymphatic contraction after hemorrhagic shock in vitro and the underlying role of nitric oxide (NO). Rat thoracic duct segments were isolated at 0, 0.5, 1, 2 and 3 h after hemorrhagic shock. Using Pressure Myograph System, we determined contraction frequency (CF), end systolic diameter (ESD), end diastolic diameter (EDD) and passive diameter (PD) of isolated rat lymphatics under different transmural pressures (1, 3, 5, 7 and 9 cmH 2 O), then cal... |
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| Keywords: | hemorrhagic shock lymphatics contractility nitric oxide |
| 本文献已被 CNKI PubMed 等数据库收录！ |
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