| 血管紧张素AT1受体抗体阳性孕鼠后代高盐饮食后血管功能障碍 |
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| 引用本文： | Zhang X,Zhang SL,Xiong HY,DU YH,Quan L,Yang J,Ma XR,Liu HR. 血管紧张素AT1受体抗体阳性孕鼠后代高盐饮食后血管功能障碍[J]. 生理学报, 2011, 63(2): 149-154 |
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| 作者姓名： | Zhang X Zhang SL Xiong HY DU YH Quan L Yang J Ma XR Liu HR |
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| 作者单位： | 首都医科大学基础医学院病理生理教研室;山西医科大学生理学系;山西省心血管疾病医院心内科; |
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| 基金项目： | supported by the Funding Project for Academic Human Resources Development in Institutions of Higher Learning under the Jurisdiction of Beijing Municipality(No.10850302); Natural Science Foundation of Shanxi Province,China(No.30900584) |
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| 摘 要： | 血管紧张素AT1受体抗体(AT1-Ab)可损伤胎盘发育,进而导致胎儿宫内生长受限(intrauterine growth restriction,IUGR).根据胎儿源性成人疾病学说,IUGR会明显增加成人后患心血管疾病的几率.本研究旨在观察AT1-Ab阳性孕鼠后代生长至成年后血管功能有无异常.24只雌性Wistar大...
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| 关 键 词： | 血管紧张素 AT1受体 抗体 胎儿源性成人疾病 高盐饮食 血管环 |
Vascular dysfunction in the offspring of AT1 receptor antibody-positive pregnant rats during high-salt diet |
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| Zhang Xi,Zhang Su-Li,Xiong Hai-Yan,DU Yun-Hui,Quan Lin,Yang Jie,Ma Xiu-Rui,Liu Hui-Rong. Vascular dysfunction in the offspring of AT1 receptor antibody-positive pregnant rats during high-salt diet[J]. Acta Physiologica Sinica, 2011, 63(2): 149-154 |
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| Authors: | Zhang Xi Zhang Su-Li Xiong Hai-Yan DU Yun-Hui Quan Lin Yang Jie Ma Xiu-Rui Liu Hui-Rong |
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| Affiliation: | ZHANG Xi1,ZHANG Su-Li2,XIONG Hai-Yan1,DU Yun-Hui1,QUAN Lin1,YANG Jie1,MA Xiu-Rui3,LIU Hui-Rong1,2,1Department of Pathophysiology,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China,2Department of Physiology,Shanxi Medical University,Taiyuan 030001,3Shanxi Cardiovascular Hospital,Taiyuan 030024 |
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| Abstract: | Antibody against the angiotensin AT1 receptor(AT1-Ab) could disturb placental development.The placenta is the key organ between mother and fetus.Placental damage will seriously impair fetal growth and development in utero,leading to intrauterine growth restriction(IUGR).Based on the fetal origins of adult disease(FOAD) hypothesis,IUGR could increase a propensity to develop adult onset cardiovascular disease(CVD).The present study was designed to determine whether vascular function has changed in the adult o... |
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| Keywords: | antibody angiotensin AT1 receptor fetal origins of adult disease high-salt diet vascular ring |
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