A model for cooperative ligand binding at complementary sites of DNA |
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Authors: | Subhendu Ghosh Anjali Mookerjee |
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Institution: | (1) School of Environmental Sciences, Jawaharlal Nehru University, 110067 New Delhi, India |
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Abstract: | The process of cooperative binding of ligands to DNA has been classified into different modes. An additional mode of cooperative
interaction amongst ligands binding at sites on complementary strands has been emphasised. A statistical mechanical method
has been applied to obtain an analytical expression for the fraction of nucleotide sites bound. Theoretical Scatchard plots
have been drawn and analysed. |
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