Substrate specificity and screening of the integral membrane protease Pla |
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Authors: | Agarkov Anton Chauhan Sadhana Lory Pedro J Gilbertson Scott R Motin Vladimir L |
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Affiliation: | Chemical Biology Program, Department of Pharmacology and Toxicology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0650, USA. |
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Abstract: | This paper reports a study to find small peptide substrates for the important virulence factor of Yersinia pestis, plasminogen activator, Pla. The method used to find small substrates for this protease is reported along with studies examining the ability of these peptides to inhibit activity of the enzyme. Through the use of parallel synthesis and positional scanning, small tripeptides were identified that are viable substrates for the protease. |
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