Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships |
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Authors: | Hosono Tetsuji Yokomizo Kazumi Hamasaki Akiyuki Okamoto Yoshinari Okawara Tadashi Otsuka Masami Mukai Ryozaburo Suzuki Keitarou |
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Affiliation: | Laboratory of Medicinal Microbiology, Yokohama College of Pharmacy, Kanagawa 245-0066, Japan. t.hosono@hamayaku.ac.jp |
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Abstract: | The compound named Histidine-pyridine-histidine (HPH) is an oxygen-activating ligand derived from the structure of bleomycin. We synthesized HPH derivatives, namely HPH-1 to -8, and investigated their antiviral activities against herpes simplex virus type 1. HPH-8 showed potent antiviral activity with an EC50 of 15 microM, and relatively high cytotoxicity with a CC50 of 37 microM. In contrast, HPH-4 indicated a weaker antiviral activity with an EC50 of 79 microM, but exhibited a far more less cytotoxicity (CC50 500 microM). Other HPH derivatives showed no effects against antiviral activities and cytotoxicities. |
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