|
|||||
|
|
Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR |
|
| Authors: | Angell Richard M Angell Tony D Bamborough Paul Brown David Brown Murray Buckton Jacky B Cockerill Stuart G Edwards Chris D Jones Katherine L Longstaff Tim Smee Penny A Smith Kathryn J Somers Don O Walker Ann L Willson Malcolm |
| Institution: | GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK. |
| Abstract: | The biphenyl amides are a novel series of p38 MAP kinase inhibitors. Structure-activity relationships of the series against p38alpha are discussed with reference to the X-ray crystal structure of an example. The series was optimised rapidly to a compound showing oral activity in an in vivo disease model. |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ | |