Comparison of a laboratory and a production coating spray gun with respect to scale-up |
| |
Authors: | Ronny Mueller Peter Kleinebudde |
| |
Institution: | (1) Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Universitaetsstr.1, 40225 Duesseldorf, Germany |
| |
Abstract: | A laboratory spray gun and a production spray gun were investigated in a scale-up study. Two Schlick spray guns, which are
equipped with a new antibearding cap, were used in this study. The influence of the atomization air pressure, spray gun-to
tablet bed distance, polymer solution viscosity, and spray rate were analyzed in a statistical design of experiments. The
2 spray guns were compared with respect to the spray width and height, droplet size, droplet velocity, and spray density.
The droplet size, velocity, and spray density were measured with a Phase Doppler Particle Analyzer.
A successful scale-up of the atomization is accomplished if similar droplet sizes, droplet velocities, and spray densities
are achieved in the production scale as in the laboratory scale. This study gives basic information for the scale-up of the
settings from the laboratory spray gun to the production spray gun. Both spray guns are highly comparable with respect to
the droplet size and velocity. The scale-up of the droplet size should be performed by an adjustment of the atomization air
pressure. The scale-up of the droplet velocity should be performed by an adjustment of the spray gun to tablet bed distance.
The presented statistical model and surface plots are convenient and powerful tools for scaling up the spray settings if the
spray gun is changed from laboratory spray gun to the production spray gun.
Published: January 19, 2007 |
| |
Keywords: | Atomization film coating spray gun scale-up design of experiments |
本文献已被 PubMed SpringerLink 等数据库收录! |
|