Enhanced production of dolichol,but not dolichyl phosphate,in the earliest stages of rat liver regeneration |
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| Authors: | M Marino G Bruscalupi S Spagnuolo S Leoni M T Mangiantini A Trentalance F W Hemming |
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| Institution: | (1) Department of Cellular and Developmental Biology, University of Rome I,  La Sapienza , P. le Aldo Moro, 00185 Rome, Italy;(2) Department of Biochemistry, Nottingham University and Medical School, NG7 2UH Nottingham, UK |
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| Abstract: | The regenerating liver presents a changed ability to use mevalonate 16 hr after partial hepatectomy. The dolichol content and its synthesis from mevalonate is increased, while no variation of dolichyl-P and ubiquinone parameters are detectable.The greater amount ofmevalonate utilized to form dolichol, but not dolichyl-P, in this proliferating system, raises some questions about the physiological significance of these isoprenoid compounds and about their biosynthetic sequence. |
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| Keywords: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase mevalonate dolichol dolichylphosphate ubiquinone regeneration (rat liver) |
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