| T型钙通道对心脏功能的调节作用 |
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| 引用本文： | 金松南,文今福,金景玉,曹景宇.T型钙通道对心脏功能的调节作用[J].生命的化学,2008,28(6). |
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| 作者姓名： | 金松南 文今福 金景玉 曹景宇 |
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| 作者单位： | 1. 泰山医院,泰安,271000
2. 青岛大学医学院,青岛,266021 |
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| 基金项目： | 国家自然科学基金
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山东省卫生系统中青年重点科技人才资助项目资助
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| 摘 要： | T型钙通道存在于心血管、神经和内分泌系统.T型钙通道在心脏自律性,细胞生长和心脏重塑中起关键性的作用.心脏疾病时T型钙通道表达增多.因此T型钙通道在生理和病理生理情况下均可参与心脏功能的调节.随着对钙通道研究的日益加深,可望更深刻地了解T型钙通道并研制出新的钙通道拮抗剂,这对心脏疾病的治疗策略具有重要的意义.
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| 关 键 词： | T型钙通道 心脏功能 心房钠尿肽 |
Roles of T-type calcium channels in the regulation of cardiac function |
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| Song-Nan JIN,Jin-Fu WEN,Jing-Yu JIN,Jing-Yu Cao.Roles of T-type calcium channels in the regulation of cardiac function[J].Chemistry of Life,2008,28(6). |
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| Authors: | Song-Nan JIN Jin-Fu WEN Jing-Yu JIN Jing-Yu Cao |
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| Abstract: | T-type Ca2+ channels are present in cardiovascular, neuronal, and endocrine systems. In the heart, T-type Ca2+ channels play important roles in heart automaticity, cell growth, and cardiac remodeling. The expression of T-type Ca2+ channels are shown to be increased in diseased heart. Thus, T-type Ca2+ channels might be involved in physiological and/or pathophysiological modulations of the cardiac function. Selective inhibitors of T-type Ca2+ channels may lead to the development of novel therapeutic strategi... |
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| Keywords: | mibefradil |
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