Sugar chain heterogeneity of bone and liver alkaline phosphatase in serum. |
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| Authors: | T Kuwana O Sugita M Yakata |
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| Institution: | Department of Laboratory Medicine, Niigata University School of Medicine, Japan. |
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| Abstract: | Fractionation of bone and liver alkaline phosphatase (EC 3.1.3.1; ALP) in serum by serial lectin affinity chromatography has demonstrated differences in the sugar chain structure of bone and liver ALP in serum from that previously reported in the corresponding tissues, with a lower content of high mannose or hybrid-type sugar chains and a higher content of biantennary complex-type chains. Furthermore, the bone and liver ALPs were found to differ in the latter with the bone fraction showing a greater content of fucose residues. |
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