Analysis of sister chromatid exchanges in lymphocytes cultured from 71 healthy men |
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| Authors: | Anil K. Sinha V. Ann Linscombe B. Bhaskar Gollapudi George C. Jersey Colin N. Park |
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| Affiliation: | (1) Health and Environmental Sciences-Texas Lake Jackson Research Center, The Dow Chemical Company, Freeport, Texas;(2) Health and Environmental Sciences, The Dow Chemical Company, Midland, Michigan;(3) Health and Environmental Sciences-Texas, Lake Jackson Research Center, The Dow Chemical Company, 77541 Freeport, Texas |
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| Abstract: | Sister chromatid exchanges (SCE) were analyzed in peripheral blood lymphocytes from a select group of 71 healthy men, 56 nonsmokers and 15 cigarette smokers. In addition to estimating baseline SCE, data were examined to seek relationships of SCE frequencies to age and smoking. The baseline value of 7.53 SCE per cell from the 56 nonsmokers was within the range (5.60 to 9.10 SCE/cell) reported for other human populations. No relationship was found between the mean SCE frequency per cell and age. However, a significant increase in the SCE mean value was observed in smokers as compared to nonsmokers. The results of this study are compared with those of other reports on SCE effects of age and smoking.Abbreviations BUdR 5-bromo,2-deoxyuridine - SCE sister chromatid exchange |
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| Keywords: | age BUdR lymphocyte SCE smoking |
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