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Isarfelin, a peptide with antifungal and insecticidal activities from Isaria felina |
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| Authors: | Guo Y X Liu Q H Ng T B Wang H X |
| Institution: | aDepartment of Microbiology, China Agricultural University and State Key Laboratory for Agrobiotechnology, Beijing, China bDepartment of Biochemistry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China |
| Abstract: | Isarfelin, a peptide with inhibitory activity on mycelial growth in Rhizoctonia solani and Sclerotinia sclerotiorum and insecticidal activity toward Leucania separata, was isolated from the mycelia of Isaria felina. The IC50 value of its antifungal activity against R. solani was 3.1 μg mL?1. However, it was devoid of activity toward several bacterial species including Bacillus subtilis, E. coli and Staphylococcus aureus. The isolation procedure involved ethanol extraction, adsorption on YPR II macropore adsorption resin, ethyl acetate extraction, petroleum ether precipitation and recrystallization from ethyl acetate. |
| Keywords: | Isaria felina Antifungal Insecticidal |
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