Phytochemical profile,enzyme inhibition activity and molecular docking analysis of Feijoa sellowiana O. Berg |
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| Authors: | Fatema R Saber Rehab M Ashour Ali M El-Halawany Mohamad Fawzi Mahomoodally Gunes Ak Gokhan Zengin Engy A Mahrous |
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| Institution: | aPharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt;bInstitute of Research and Development, Duy Tan University, Da Nang, Vietnam;cFaculty of Science, Department of Health Sciences, University of Mauritius, Réduit, Mauritius;dDepartment of Biology, Science Faculty, Selcuk University, Campus, Konya, Turkey |
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| Abstract: | Feijoa sellowiana leaves and fruits have been investigated as a source of diverse bioactive metabolites. Extract and eight metabolites isolated from F. sellowiana leaves were evaluated for their enzymatic inhibitory activity against α-glucosidase, amylase, tyrosinase, acetylcholinestrerase and butyrylcholinesterase both in vitro and in silico. Feijoa leaves’ extract showed strong antioxidant activity and variable levels of inhibitions against target enzymes with a strong anti-tyrosinase activity (115.85 mg Kojic acid equivalent/g). Additionally, α-tocopherol emerged as a potent inhibitor of AChE and BChE (5.40 & 10.38 mmol galantamine equivalent/g, respectively). Which was further investigated through molecular docking and found to develop key enzymatic interactions in AChE and BChE active sites. Also, primetin showed good anti BChE (11.70 mmol galantamine equivalent/g) and anti-tyrosinase inhibition (90.06 mmol Kojic acid equivalent/g) which was also investigated by molecular docking studies.Highlights- Isolation of eight bioactive constituents from Feijoa sellowiana leaves.
- In vitro assays using different enzymatic drug targets were investigated.
- In silico study was performed to define compound interactions with target proteins.
- Feijoa leaf is an excellent source of anti-AChE and antityrosinase bioactives.
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| Keywords: | Antioxidant acetylcholinesterase amylase Feijoa sellowiana glucosidase molecular docking Pineapple guava tyrosinase |
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