Uptake and release of calcium ions by heavy sarcoplasmic reticulum fraction of normal and malignant hyperthermia-susceptible human skeletal muscle |
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Institution: | 1. Department of Psychology, University of Southern Denmark, 5230 Odense, Denmark;2. Center for Brain Health, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX 75235, USA;3. Department of Psychology, University of Houston, Houston, TX 77004, USA;4. Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, UK;5. Research Department of Clinical, Educational, and Health Psychology, University College London, London WC1E 6BT, UK;6. Anna Freud Centre, London NW3 5SD, UK;7. Human Neuroimaging Laboratory, Virginia Tech Carilion Research Institute, Roanoke, VA 24016, UK |
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Abstract: | - 1.1. Ca2+ uptake, Ca2+-dependent ATPase activity and halothane-induced Ca2+ release from the heavy sarcoplasmic reticulum fraction of muscle from malignant hyperthermia susceptible individuals are similar to those of normal human muscle.
- 2.2. Ca2+-induced Ca2+ release from the diseased muscle was increased by 13%.
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