Vibrio cholerae strains with mutations in an atypical type I secretion system accumulate RTX toxin intracellularly |
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| Authors: | Boardman Bethany Kay Satchell Karla J Fullner |
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| Affiliation: | Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. |
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| Abstract: | This study shows that the Vibrio cholerae RTX toxin is secreted by a four-component type I secretion system (TISS) encoded by rtxB, rtxD, rtxE, and tolC. ATP-binding site mutations in both RtxB and RtxE blocked secretion, demonstrating that this atypical TISS requires two transport ATPases that may function as a heterodimer. |
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