Thyrotropin induces changes in the morphology and the organization of microfilament structures in cultured thyroid cells |
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Authors: | D. Tramontano A. Avivi F. S. Ambesi-Impiombato L. Barak B. Geiger J. Schlessinger |
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Affiliation: | Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel |
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Abstract: | Thyrotropin (TSH) induces morphological changes in cultures of normal rat thyroid cell lines and in primary bovine thyroid cells. It also induces a specific reorganization of the microfilaments of the thyroid cells. Both effects are fully reversible and are mimicked by 8-bromo-cAMP. These results indicate that the trophic response of TSH involves changes in the organization of the actin-containing filaments, probably mediated through cAMP, followed by changes in cell shape. |
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