Assessment of membrane protection by 31P-NMR effects of lidocaine on calcium-paradox in myocardium |
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| Authors: | H Sakai M Yoshiyama M Teragaki K Takeuchi T Takeda M Ikata M Ishikawa I Miura |
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| Affiliation: | First Department of Internal Medicine, Osaka City University Medical School, Japan. |
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| Abstract: | In studying calcium paradox, perfused rat hearts were used to investigate the myocardial protective effects of lidocaine. Intracellular contents of phosphates were measured using the 31P-NMR method. In hearts reexposed to calcium, following 3 minute calcium-free perfusion, a rapid contracture occurred, followed by rapid and complete disappearance of intracellular phosphates with no resumption of cardiac function. In hearts where lidocaine was administered from the onset of the calcium-free perfusion until 2 minutes following the onset of reexposure to calcium, both intracellular phosphates and cardiac contractility were maintained. Therefore, it can be said that cell membranes were protected by lidocaine. |
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