辛伐他汀自微乳化胶囊的体内评价

目的:研究辛伐他汀(SV)自微乳化胶囊在比格犬体内的药代动力学。方法:采用HPLC法测定比格犬血浆药物浓度,与市售片比较,考察SV自微乳化胶囊的体内药代动力学。结果:药代动力学测定结果表明:与市售片比较,自微乳化胶囊血药浓度达峰时间提前、最高血药浓度增大,Tmax=1.41h,Cmax=46.22ng.mL-1,而市售片的Tmax=2.65h,Cmax=12.43ng.mL-1;AUC0-∞为市售片剂的227.5%。结论:自微乳化胶囊可以显著提高SV的体内吸收。

Assessment of simvastatin with a self- emulsifying capsule in vivo

Objective: To evluate the self-microemulsifying ablity and dissolution behavior of simvastatin in vitro and the pharmacokinetic behavior in beagle dogs.Methods: The plasma concentrations were evaluated by HPLC and dissolution and pharmacokinetic behavior of self-microemulsifying formulations were evaluated by comparison with commercial tablets.Results: The area under the curve(AUC) was significantly higher in the simvastatin self-microemulsifying capsules group than that in the commercial tablets group.Also,T_(max) was smaller and C_(max) was much higher in the simvastatin self-microemulsifying capsules group compared with market products.Conclusion: The self-microemulsifying capsule can increase absorption in vivo significantly.