Response to DNA-damaging agents in cultured cells from patients with X-linked duchenne muscular dystrophy phenotype: male DMD,female DMD,possible carriers |
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Authors: | Laura Barsi Giovanni Meola Mariaelena Velicogna Cristiana Bonifati Anna Maria Fuhrman Conti Guglielmo Scarlato |
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Affiliation: | (1) Centro Dino Ferrari, Istituto di Clinica Neurologica, Milano, Italy;(2) Dipartimento di Biologia e Genetica per le Scienze Mediche, Università di Milano, Milano, Italy |
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Abstract: | Using blood cultures the response to gamma () radiation was examined in a male DMD and his mother, in a female DMD and her mother and in a normal control. In a series of experiments chromosome aberrations were determined after 3 separate -irradiation dose levels: 0, 150, 300 rads. The DMD patients showed a response to ionising radiations different from control, in fact the percentage of aberrations was lower than the control. In this preliminary study a slight difference between normal and possible carriers was also found. |
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Keywords: | blood cultures carriers DNA-damaging agents duchenne muscular dystrophy ionising radiations |
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