5-Propynylamino alpha-deoxyuridine promotes DNA duplex stabilization of anionic and neutral but not cationic alpha-oligonucleotides |
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| Authors: | Deglane Gaëlle Morvan François Debart Françoise Vasseur Jean-Jacques |
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| Affiliation: | LCOBS, UMR 5625 CNRS-UM II, Université Montpellier II, 34095 Montpellier, France. |
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| Abstract: | Incorporation of 5-propynylamino and 5-propynyl alpha-2'-deoxyuridine into alpha-oligonucleotides (alpha-ON) allows high-affinity targeting of complementary DNA for alpha-ON with anionic and neutral backbone but not for cationic alpha-ON, revealing clues on the role of the amino group of the propynylamino on the formation of DNA duplexes. |
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