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A biologically active fragment of the differentiation factor of the HL-60 line cells: Identification and properties |
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| Authors: | I. A. Kostanyan M. V. Astapova E. V. Navolotskaya T. N. Lepikhova S. M. Dranitsyna G. B. Telegin I. L. Rodionov L. K. Baidakova Yu. A. Zolotarev I. M. Molotkovskaya V. M. Lipkin |
| Affiliation: | (1) Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, 117871 GSP-7 Moscow, Russia;(2) Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, 142290 Pushchino, Moscow oblast, Russia;(3) Institute of Molecular Genetics, Russian Academy of Sciences, Moscow |
| Abstract: | Six-membered peptide fragment TGENHR (HLDF-6) was identified in the HL-60 cell culture of human promyelocyte leukemia treated with retinoic acid when studying the differentiation factor HLDF of this cell line. HLDF-6 retains the ability of the full-size factor to induce the differentiation and arrest the proliferation of the starting HL-60 cells. It was shown that the synthetic peptide HLDF-6 has no specific receptors on the surface of the HL-60 cells but can affect the binding of interleukin IL-1β, a cytokine involved in proliferation, to the cell surface. It was found on a model of transplantable NSO myeloma that HLDF-6 has an antitumor activity. |
| Keywords: | cell differentiation factor biologically active fragment peptide HL-60 cell line |
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