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A biologically active fragment of the differentiation factor of the HL-60 line cells: Identification and properties |
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| Authors: | I A Kostanyan M V Astapova E V Navolotskaya T N Lepikhova S M Dranitsyna G B Telegin I L Rodionov L K Baidakova Yu A Zolotarev I M Molotkovskaya V M Lipkin |
| Institution: | (1) Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, 117871 GSP-7 Moscow, Russia;(2) Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, 142290 Pushchino, Moscow oblast, Russia;(3) Institute of Molecular Genetics, Russian Academy of Sciences, Moscow |
| Abstract: | Six-membered peptide fragment TGENHR (HLDF-6) was identified in the HL-60 cell culture of human promyelocyte leukemia treated with retinoic acid when studying the differentiation factor HLDF of this cell line. HLDF-6 retains the ability of the full-size factor to induce the differentiation and arrest the proliferation of the starting HL-60 cells. It was shown that the synthetic peptide HLDF-6 has no specific receptors on the surface of the HL-60 cells but can affect the binding of interleukin IL-1β, a cytokine involved in proliferation, to the cell surface. It was found on a model of transplantable NSO myeloma that HLDF-6 has an antitumor activity. |
| Keywords: | cell differentiation factor biologically active fragment peptide HL-60 cell line |
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