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Intracellular calcium in cystic fibrosis heterozygotes |
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| Authors: | B L Shapiro L F Lam |
| Affiliation: | 1. Department of Computer and Information Science and Engineering, University of Florida, Florida 32611, USA;2. Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Florida 32610, USA;3. Department of Epidemiology, College of Public Health and Health Professions & College of Medicine, University of Florida, Florida 32610, USA;1. Sterling Professor of Economics and Professor of Statistics at Yale University, New Haven, CT, United States;2. Professor of Economics at Korea University, Seoul, Republic of Korea |
| Abstract: | Increased intracellular calcium (Ca) has been reported in several cell types in cystic fibrosis (CF). Because CF is an autosomal recessive trait examination of asymptomatic obligate carriers (HZ) of the gene is a powerful way to determine the relevance of this observation to the abnormal gene product. We report here that Ca as determined by atomic absorption spectrophotometry in cultured skin fibroblasts and circulating lymphocytes is greater in HZ than in control cells. Since an intracellular Ca increase is expressed in HZ the Ca differences in CF likely reflect action of the gene product responsible for CF and not some secondary or tertiary effect of the disease. |
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