Silicon and iron levels in tissues of animals treated with a “ferrimagnetic ceramic” with oncotherapeutic potential (anti-tumor) value

The stability in a biological environment of an injectable cement with oncotherapeutic potential — consisting of a glass powder of SiO₂ (35.6%), CaO (42.4%), P₂O₅ (17%), Na₂O (5%) and 30% of its weight of Fe₃O₄ dissolved in (NH₄)₂HPO₄ plus NH₄H₂PO₄ — was evaluated referring to the release of silicon and iron. The experimental model was the rat, and organs (liver, kidney, spleen, lung, heart, and brain) of the implanted and control animals were collected for quantification of these elements by electrothermal atomization atomic absorption spectrometry methods. In most of the analysed organs no significant difference in the contents of silicon and iron between the implanted and the control animals was found.