Two ligands signal through the Drosophila PDGF/VEGF receptor to ensure proper salivary gland positioning |
| |
Authors: | Harris Katherine E Schnittke Nikolai Beckendorf Steven K |
| |
Affiliation: | Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA |
| |
Abstract: | The Drosophila embryonic salivary gland is a migrating tissue that undergoes a stereotypic pattern of migration into the embryo. We demonstrate that the migratory path of the salivary gland requires the PDGF/VEGF pathway. The PDGF/VEGF receptor, Pvr, is strongly expressed in the salivary glands, and Pvr mutations cause abnormal ventral curving of the glands, suggesting that Pvr is involved in gland migration. Although the Pvr ligands, Pvf1 and Pvf2, have distinct expression patterns in the Drosophila embryo, mutations for either one of the ligands result in salivary gland migration defects similar to those seen in embryos that lack Pvr. Rescue experiments indicate that the PDGF/VEGF pathway functions autonomously in the salivary gland. The results of this study demonstrate that the Drosophila PDGF/VEGF pathway is essential for proper positioning of the salivary glands. |
| |
Keywords: | Pvr Pvf1 Pvf2 Pvf3 VEGF PDGF Salivary gland Cell migration Drosophila |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|