Synthesis and evaluation of phenoxy acetic acid derivatives as [corrected] anti-mycobacterial agents |
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Authors: | Shaharyar Mohammad yar Mohammad Shahar Siddiqui Anees Ahmad Ali Mohamed Ashraf |
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Institution: | Faculty of Pharmacy, Jamia Hamdard University, Department of Pharmaceutical Chemistry, Hamdard Nagar, New Delhi, India. yarmsy@rediffmail.com |
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Abstract: | In present investigation, 2-(4-formyl-2-methoxyphenoxy) acetic acid on condensation with various ketones in methanolic KOH solution yielded the corresponding chalcones (1-3). These corresponding chalcones were reacted with appropriate acid hydrazide in glacial acetic acid led to the formation of phenoxy acetic acid derivatives. All newly synthesized compounds were evaluated for their anti-mycobacterial activities against Mycobacterium tuberculosis H(37)Rv. |
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