Hypothalamic Proline Rich Polypeptide Regulates Hematopoiesis |
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Authors: | Kristina B Bezirganyan Tigran K Davtyan Armen A Galoyan |
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Institution: | (1) H. Buniatian Institute of Biochemistry, NAS RA, 5/1 Sevag Str., Yerevan, 375014, Republic of Armenia; |
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Abstract: | The AGAPEPAEPAQPGVY proline-rich polypeptide (PRP-1) was isolated from neurosecretory granules of the bovine neurohypophysis;
it is produced by N. supraopticus and N. paraventricularis. It has been shown that PRP-1 has many potentially beneficial biological effects including immunoregulatory, hematopoietic,
antimicrobial and anti-neurodegenerative properties. Here we demonstrated that PRP-1 administration influence on redistribution
of monocytes, granulocytes and lymphocytes between bone marrow (BM) and peripheral blood and promotes the influx of granulocytes
and monocytes/macrophages from BM into peripheral blood and accumulation of immature granulocyte and monocyte in BM and delayed
the maturation of T cells in BM. PRP-1 increased colony-forming cell proliferation in rat cells in vivo. In PRP-treated rat
BM, the CFU number at day 4, 7 and 14 was considerably increased in comparison with untreated rats BM and no difference was
found at day 21 and day 28. We found that PRP-1 enhances erythroid and myeloid colonies formation in human CD34+ progenitor cell culture in the presence of different growth factors and down-regulates T cells colony formation and specific
surface markers expression during induction of human CD34+ progenitor cells differentiation into T lymphocytes lineage. We suggested that the hypothalamic PRP-1 possibly represents
an endogenous peptide whose primary functions are to regulate neuronal survival and differentiation and hematopoiesis within
neurosecretory hypothalamus—bone marrow humoral axis. |
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