Synthesis of triterpenoid acylates: Effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses |
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| Authors: | O B Kazakova N I Medvedeva I P Baikova G A Tolstikov T V Lopatina M S Yunusov L Zaprutko |
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| Institution: | 1.Institute of Organic Chemistry, Ufa Scientific Center,Russian Academy of Sciences,Ufa,Russia;2.Organic Chemistry Department,Poznan University of Medical Sciences,Poznan,Poland |
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| Abstract: | The synthesis of a new group of triterpenoid acylates has been conducted on the basis of oleanolic, glycyrrhetic, and ursolic
acids and betulin. 28-ortho-Methoxycynnamoylbetulin has been demonstrated to possess high activity against the influenza type A (H1N1) virus with the
selectivity index SI > 100 while studying the activity of the synthesized compounds in relation to the reproduction of viral
pathogens of respiratory infections. The high activity of 3,28-dinicotinoylbetulin against the papilloma virus (strain HPV-11)
was detected with the selectivity index SI 35. |
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