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Aripiprazole, An Atypical Antipsychotic Drug, Improves Maturation and Complexity of Neuroblast Dendrites in the Mouse Dentate Gyrus Via Increasing Superoxide Dismutases |
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| Authors: | Bai Hui Chen Bing Chun Yan Joon Ha Park Ji Hyeon Ahn Dae Hwan Lee In Hye Kim Jeong-Hwi Cho Jae-Chul Lee Sung Koo Kim Bonghee Lee Jun Hwi Cho Moo-Ho Won Yun Lyul Lee |
| Affiliation: | 1. Department of Physiology, Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon, 200-702, South Korea 2. Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, 200-701, South Korea 3. Institute of Integrative Traditional and Western Medicine, Medical College, Yangzhou University, Yangzhou, 225001, China 4. Laboratory of Neuroscience, Department of Physical Therapy, College of Rehabilitation Science, Daegu University, Gyeongsan, 712-714, South Korea 5. Department of Pediatrics, School of Medicine, Dongtan Sacred Heart Hospital, Hallym University, Hwaseong, 445-170, South Korea 6. Center for Genomics and Proteomics, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Incheon, 406-840, South Korea 7. Department of Emergency Medicine, Institute of Medical Sciences, School of Medicine, Kangwon National University Hospital, Kangwon National University, Chuncheon, 200-701, South Korea |
| Abstract: | Apripiprazole (APZ) is well known as an atypical antipsychotic and antidepressant. In the present study, we investigated effects of APZ on cell proliferation and neuronal differentiation in the dentate gyrus (DG) of the adolescent mouse using BruU, Ki-67 and doublecortin (DCX) immunohistochemistry. BruU, Ki-67 and DCX-positive (+) cells were easily detected in the subgranular zone of the DG in the vehicle- and APZ-treated group. We found that in the 8 mg/kg APZ-treated group numbers of Ki-67+, DCX+ and BrdU+/DCX+ cells were significantly increased compared with those in the vehicle-treated group. We also found that maturation and complexity of DCX+ dendrites in the 8 mg/kg APZ-treated group was well improved compared with those in the vehicle-treated group. In addition, markedly decreased lipid peroxidation and increased superoxide dismutase 2 (SOD2) level were observed in the DG of the 8 mg/kg APZ-treated group. Our present findings indicate that APZ can enhance cell proliferation and neuroblast differentiation, particularly maturation and complexity of neuroblast dendrites, in the DG via decreasing lipid peroxidation and increasing SOD2 level. |
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