Regulatory role of cathepsin D in apoptosis |
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Authors: | Minarowska Alina Minarowski Lukasz Karwowska Alicja Gacko Marek |
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Institution: | 3rd Department of Children's Diseases, Medical University of Bia?ystok, Poland. minar@mp.pl |
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Abstract: | Cathepsin D (CTSD, EC 3.4.23.5) is well known aspartyl protease. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. Cathepsin D can either induce apoptosis in presence of cytotoxic factors, but in certain studies an inhibitory role in apoptosis was also reviewed. Detailed review of involvement of cathepsin D in cell apoptosis is a purpose of this paper. |
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