Increased near-ultraviolet induced DNA fragmentation in xeroderma pigmentosum variants.期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Increased near-ultraviolet induced DNA fragmentation in xeroderma pigmentosum variants.

Authors:	M S Netrawali P A Cerutti

Affiliation:	1. Department of Carcinogenesis Swiss Institute for Experimental Cancer Research CH-1066 Epalinges / Lausanne - Switzerland;2. Department of Biochemistry and Molecular Biology University of Florida, Box J245, JHMHC Gainesville, Florida 32610 USA

Abstract:	Immediate fragmentation of parental DNA by near-ultraviolet irradiation at 313 nm was measured in cultured skin fibroblasts from normal individuals, patients with Xeroderma pigmentosum of complementation group A (XPA) and Xeroderma pigmentosum variants (XPV) by the alkaline elution procedure. For a dose of 2.25 KJm^?2 given at O^o fragmentation was comparable in all cell strains. However, fragmentation was strongly increased relative to O^o in XPV but not in normal fibroblasts and the XPA strains when irradiation was carried out at 37^o. From our results it appears that a step in the repair of $parental$ DNA is abnormal in XPV.

Keywords:	XPA Xeroderma pigmentosum skin fibroblasts of complementation group A XPV skin fibroblasts from Xeroderma pigmentosum variants PBS phosphate buffered saline
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