Biaryl diamides as potent melanin concentrating hormone receptor 1 antagonists |
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| Authors: | Palani Anandan Shapiro Sherry McBriar Mark D Clader John W Greenlee William J O'Neill Kim Hawes Brian |
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| Affiliation: | Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. anandan.palani@spcorp.com |
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| Abstract: | Herein, we report the discovery of the potent and selective biaryl diamide derived MCH-R1 receptor antagonist 1, which was identified upon modification of a previously disclosed biaryl urea series. This paper describes one of the strategies incorporated to remove the highly mutagenic biarylaniline present in an otherwise promising biaryl urea series. |
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