Gene polymorphisms and chronic obstructive pulmonary disease |
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Authors: | Xiaodan Wu Bowei Yuan Elena López Chunxue Bai Xiangdong Wang |
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Affiliation: | aDepartment of Respiratory Medicine Zhongshan Hospital, Fudan University, Shanghai, China;bShanghai Respiratory Research Institute, Shanghai, China;cHarbin Medical University, Harbin, China;dDepartment of Oncohematology of Children, Hospital Universitario Niño Jesús, Madrid, Spain |
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Abstract: | The genetic component was suggested to contribute to the development of chronic obstructive pulmonary disease (COPD), a major and growing public health burden. The present review aims to characterize the evidence that gene polymorphisms contribute to the aetiology of COPD and related traits, and explore the potential relationship between certain gene polymorphisms and COPD susceptibility, severity, lung function, phenotypes, or drug effects, even though limited results from related studies lacked consistency. Most of these studies were association studies, rather than confirmatory studies. More large‐sized and strictly controlled studies are needed to prove the relationship between gene polymorphisms and the reviewed traits. More importantly, prospective confirmatory studies beyond initial association studies will be necessary to evaluate true relationships between gene polymorphisms and COPD and help individualized treatment for patients with COPD. |
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Keywords: | chronic lung diseases
COPD
gene biomarkers polymorphism therapy |
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