Amniotic mesenchymal stem cells display neurovascular tropism and aid in the recovery of injured peripheral nerves |
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| Authors: | YongNan Li Longzhe Guo Hyun Sook Ahn Moo Hyun Kim Sung‐Whan Kim |
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| Institution: | 1. Department of Neurology, The Fourth Affiliated Hospital, Harbin Medical University, , Harbin, Heilongjiang, China;2. Department of Cardiology, College of Medicine, Dong‐A University, , Busan, Korea;3. Regional Clinical Trial Center, Dong‐A University Hospital, , Busan, Korea;4. Department of Obstetrics and Gynecology, Ilsin Christian Hospital, , Busan, Korea;5. Department of Anatomy and Cell Biology and Mitochondria Hub Regulation Center, College of Medicine, Dong‐A University, , Busan, Korea;6. Innovative Cell & Gene Therapy Center, International St.Mary's Hospital, , Incheon, Korea |
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| Abstract: | Recently, we reported that human amniotic membrane‐derived mesenchymal stem cells (AMMs) possess great angiogenic potential. In this study, we determined whether local injection of AMMs ameliorates peripheral neuropathy. AMMs were transplanted into injured sciatic nerves. AMM injection promoted significant recovery of motor nerve conduction velocity and voltage amplitude compared to human adipose‐derived mesenchymal stem cells. AMM implantation also augmented blood perfusion and increased intraneural vascularity. Whole‐mount fluorescent imaging analysis demonstrated that AMMs exhibited higher engraftment and endothelial incorporation abilities in the sciatic nerve. In addition, the higher expression of pro‐angiogenic factors was detected in AMMs injected into the peripheral nerve. Therefore, these data provide novel therapeutic and mechanistic insights into stem cell biology, and AMM transplantation may represent an alternative therapeutic option for treating peripheral neuropathy. |
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| Keywords: | amniotic stem cells angiogenesis cell therapy engraftment peripheral nerve |
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