Anchored protein kinase A signalling in cardiac cellular electrophysiology |
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Authors: | Siddarth Soni Arjen Scholten Marc A Vos Toon AB van Veen |
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Institution: | 1. Division of Heart & Lungs, Dept of Medical Physiology, University Medical Centre Utrecht, , Utrecht, The Netherlands;2. Biomolecular Mass Spectrometry & Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, , Utrecht, The Netherlands;3. Netherlands Proteomics Centre, , Utrecht, The Netherlands |
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Abstract: | The cyclic adenosine monophosphate (cAMP)‐dependent protein kinase (PKA) is an elementary molecule involved in both acute and chronic modulation of cardiac function. Substantial research in recent years has highlighted the importance of A‐kinase anchoring proteins (AKAP) therein as they act as the backbones of major macromolecular signalling complexes of the β‐adrenergic/cAMP/PKA pathway. This review discusses the role of AKAP‐associated protein complexes in acute and chronic cardiac modulation by dissecting their role in altering the activity of different ion channels, which underlie cardiac action potential (AP) generation. In addition, we review the involvement of different AKAP complexes in mechanisms of cardiac remodelling and arrhythmias. |
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Keywords: |
PKA
AKAPs signal transduction beta adrenergic signalling |
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