Effect of nifedipine administration on the functional capacity of neutrophils |
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Authors: | N Kaul K I Andrabi N K Ganguly P L Wahi |
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Institution: | (1) Departments of Cardiology and Experimental Medicine, Postgraduate Institute of Medical Education and Research, 160012 Chandigarh, India;(2) Division of Cardiovascular Sciences, St. Boniface. Gen. Hosp. Research Ctr., 351 Tache Ave, R2H 2A6 Winnipeg, Canada |
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Abstract: | Administration of nifedipine to mice over a period of six months caused a significant (p<0.05) decrease in neutrophilic functions viz superoxide generation, coupled to NADPH oxidase activity as well as NADPH production by HMP shunt. Properties like chemotaxis and phagocytosis showed a similar decrease. From this study, it is seen that nifedipine causes neutrophil functional abrogation which is therefore an apparent concern for the prolonged usage of the drug. However, relevance of the mouse model to clinical situation needs further investigation. |
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Keywords: | neutrophils nifedipine superoxide chemotaxis phagocytosis NADPH |
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