Leishmanicidal and Anticandidal Activity of Constituents of Indian Edible Mushroom Astraeus hygrometricus |
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Authors: | Tapan K Lai Gunjan Biswas Soumya Chatterjee Aritri Dutta Chiranjib Pal Julie Banerji Nattamai Bhuvanesh Joseph H Reibenspies Krishnendu Acharya |
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Affiliation: | Department of Chemistry, Vidyasagar Evening College, 39, Sankar Ghosh Lane, Kolkata 700006, India. |
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Abstract: | Two new lanostane-type triterpenes, 1 and 2, were isolated from Astraeus hygrometricus. The structures were established by IR, (1) H- and (13) C-NMR, MS, and X-ray crystallographic experiments. The triterpenes exhibited excellent in vitro toxicities against Candida albicans, comparable to standard antifungal antibiotics. The triterpene 2 significantly inhibited the growth of Leishmania donovani promastigotes in vitro. The triterpene skeleton may be considered a template structure in search for new compounds with anticandidal and leishmanicidal activity. |
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