Zinc and Iron Concentration and SOD Activity in Human Semen and Seminal Plasma |
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| Authors: | Urszula Marzec-Wróblewska Piotr Kamiński Paweł Łakota Marek Szymański Karolina Wasilow Grzegorz Ludwikowski Magdalena Kuligowska-Prusińska Grażyna Odrowąż-Sypniewska Tomasz Stuczyński Jacek Michałkiewicz |
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| Affiliation: | (1) Department of Ecology and Environmental Protection, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland;(2) Department of Animal Biotechnology, University of Technology and Life Sciences, Bydgoszcz, Poland;(3) Department of Obstetrics, Female Pathology and Oncological Gynecology, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, University Hospital No. 2, Bydgoszcz, Poland;(4) NZOZ Medical Center, Bydgoszcz, Poland;(5) Family Medicine Clinic, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, University Hospital No. 2, Bydgoszcz, Poland;(6) Department of Clinical Andrology, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, University Hospital No. 2, Bydgoszcz, Poland;(7) Department of Laboratory Diagnostics, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland;(8) Department of Soil Structure, Institute of Soil and Plant Cultivation, Government Scientific Institute, Puławy, Poland;(9) Department of Immunology, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland |
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| Abstract: | The aim of the present study was to measure zinc (Zn) and iron (Fe) concentration in human semen and superoxide dismutase (SOD) activity in seminal plasma and correlate the results with sperm quality. Semen samples were obtained from men (N = 168) undergoing routine infertility evaluation. The study design included two groups based on the ejaculate parameters. Group I (n = 39) consisted of males with normal ejaculate (normozoospermia), and group II (n = 129) consisted of males with pathological spermiogram. Seminal Zn and Fe were measured in 162 samples (group I, n = 38; group II, n = 124) and SOD activity in 149 samples (group I, n = 37; group II, n = 112). Correlations were found between SOD activity and Fe and Zn concentration, and between Fe and Zn concentration. SOD activity was negatively associated with volume of semen and positively associated with rapid progressive motility, nonprogressive motility, and concentration. Negative correlation was stated between Fe concentration and normal morphology. Mean SOD activity in seminal plasma of semen from men of group I was higher than in seminal plasma of semen from men of group II. Fe concentration was higher in teratozoospermic males than in males with normal morphology of spermatozoa in group II. Our results suggest that Fe may influence spermatozoa morphology. |
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