The Antiarrhythmic Effect of n-3 Polyunsaturated Fatty Acids: Modulation of Cardiac Ion Channels as a Potential Mechanism |
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Authors: | Email author" target="_blank">Y-F?XiaoEmail author DC?Sigg A?Leaf |
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Institution: | (1) Cardiac Rhythm Management, Medtronic Inc., Minneapolis, MN 55432, USA;(2) Departments of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA |
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Abstract: | Sudden cardiac death remains one of the most serious medical challenges in Western countries. Increasing evidence in recent
years has demonstrated that the n-3 polyunsaturated fatty acids (PUFAs) can prevent fatal ventricular arrhythmias in experimental
animals and probably in humans. Dietary supplement of fish oils or intravenous infusion of the n-3 PUFAs prevents ventricular
fibrillation caused by ischemia/reperfusion. Similar antiarrhythmic effects of these fatty acids are also observed in cultured
mammalian cardiomyocytes. Based on clinical observations and experimental studies in vitro and in vivo, several mechanisms
have been postulated for the antiarrhythmic effect of the n-3 PUFAs. The data from our laboratory and others have shown that
the n-3 PUFAs are able to affect the activities of cardiac ion channels. The modulation of channel activities, especially
voltage-gated Na+ and L-type Ca2+ channels, by the n-3 fatty acids may explain, at least partially, the antiarrhythmic action. It is not clear, however, whether
one or more than one mechanism involves the beneficial effect of the n-3 PUFAs on the heart. This article summarizes our recent
studies on the specific effects of the n-3 PUFAs on cardiac ion channels. In addition, the effect of the n-3 PUFAs on the
human hyperpolarization-activated cyclic-nucleotide-modulated channel is presented. |
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Keywords: | Cardiac arrhythmia Eicosapentaenoic acid Docosahexaenoic acid Hyperpolarization-activated cyclic-nucleotide-modulated channel Mutation |
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