Frequency of HLA-G exon 8 polymorphisms and kidney allograft outcome in Iranian population |
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Authors: | Mahdokht H Aghdaie Negar Azarpira Kurosh Kazemi Bita Geramizadeh Masumeh Darai Seid Ali Malekhoseini |
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Institution: | (1) Organ Transplant Research Center, Nemazi Hospital, Shiraz University of Medical Sciences, Zand Street, 7193711351 Shiraz, Iran;(2) Transplant Center, Shiraz University of Medical Sciences, Shiraz, Iran; |
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Abstract: | The 14-bp polymorphism in exon 8 of the HLA-G gene is associated with HLA-G mRNA stability and the patterns of alternative
isoform splicing and may influence the functionality of the HLA-G molecule. HLA-G expression was related to allograft acceptance
and fewer episodes of acute rejection during heart, kidney and liver–kidney transplantation. In order to determine a possible
correlation between the 14-bp insertion/deletion polymorphism and kidney allograft outcome in our population, genomic DNA
was isolated from 144 patients who had received isolated kidney allografts. The recipients was divided into two groups, grafts
presenting features of rejection group and a non-rejection group, and compared them with a control group of 100 healthy subjects.
There was no significant difference in allelic frequencies of 14-bp insertion/deletion polymorphism between normal controls
and kidney transplant patients. No significant difference was found between the RG and the NRG regarding the 14-bp genotypes
and alleles. Therefore, additional studies with more sample size from other populations with analysis of other HLA-G polymorphisms
are necessary to define this polymorphism as a valuable clinical marker. |
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